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Induction of pluripotent stem cells from adult human fibroblasts

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Cell , 01 Nov , 5 : DOI: Read article at publisher's site DOI : Inflamm Regen , , 13 Jan Transl Neurodegener , , 07 Jan

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Turning Somatic Cells into Pluripotent Stem Cells

Enhanced Generation of Induced Pluripotent Stem Cells from a Subpopulation of Human Fibroblasts

This page has been archived and is no longer updated. During embryonic development , specialized cells e. Scientists can recover these embryonic stem ES cells from embryos and manipulate them in vitro to study early development. They can also differentiate ES cells into cell types that are useful for therapeutic purposes, such as transplantation. This technology raises a significant ethical concern because most ES cells arise from human embryos. Some ethical concerns may be circumvented by the discovery that somatic cells can be reprogrammed to a pluripotent state. The reprogrammed cells, called induced pluripotent stem iPS cells, exhibit functional similarities to ES cells and present an exciting area of research.

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Blood ; 3 : — The concept of reprogramming of somatic cells has opened a new era in regenerative medicine. Transduction of defined factors has successfully achieved pluripotency. However, during the generation process of induced pluripotent stem iPS cells, genetic manipulation of certain factors may cause tumorigenicity, which limits further application. We report that that a single transfer of embryonic stem ES cell—derived proteins into primarily cultured adult mouse fibroblasts, rather than repeated transfer or prolonged exposure to materials, can achieve full reprogramming up to the pluripotent state without the forced expression of ectopic transgenes.

The derivation of induced pluripotent stem cells iPSCs provides new possibilities for basic research and novel cell-based therapies. Limitations, however, include our current lack of understanding regarding the underlying mechanisms and the inefficiency of reprogramming. Here, we report identification and isolation of a subpopulation of human dermal fibroblasts that express the pluripotency marker stage specific embryonic antigen 3 SSEA3. Transcriptional analysis revealed NANOG expression was significantly increased in the SSEA3 expressing fibroblasts, suggesting a possible mechanistic explanation for the differential reprogramming.