Duchenne muscular dystrophy DMD is the most common sex linked lethal disease in man one case in about male live births. The patients are wheelchair bound around the age of years and usually die before the age of 20 years. The mutation rate, estimated by different methods and from different population studies, is in the order of 7 X 10 -5 , which is higher than for any other X-linked genetic disease. Moreover, unlike other X linked diseases such as hemophilia A or Lesh-Nyhan's disease, there seems to be no sex difference for the mutation rates in DMD. Several observations of DMD in girls bearing X-autosomal translocations and linkage studies on two X chromosomal DNA restriction fragment length polymorphisms indicate that the DMD locus is situated on the short arm of the X chromosome, between Xp11 and Xp
Duchenne Muscular Dystrophy: Pathogenetic Aspects and Genetic Prevention
Sex-linked diseases are passed down through families through one of the X or Y chromosomes. X and Y are sex chromosomes. Dominant inheritance occurs when an abnormal gene from one parent causes disease, even though the matching gene from the other parent is normal. The abnormal gene dominates. But in recessive inheritance, both matching genes must be abnormal to cause disease.
Is muscular dystrophy autosomal or sex-linked?
What is muscular dystrophy? Muscular dystrophy MD refers to a group of more than 30 genetic diseases that cause progressive weakness and degeneration of skeletal muscles used during voluntary movement. The word dystrophy is derived from the Greek dys, which means "difficult" or "faulty," and troph, or "nourish.
It causes difficulty in walking at about the age of four years, loss of the ability to walk at about the age of 11, and death before the age of 20, usually because of respiratory failure or…. Pseudohypertrophic muscular dystrophy is a rare variety of the disease that begins before puberty, is more common in males, and usually progresses to severe disability within a few years. The other types of dystrophy, in general, begin in adolescence or young adulthood, equally affect males….